Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei
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چکیده
منابع مشابه
Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei.
Leptin has profound effects on feeding, metabolism, and neuroendocrine status. Evidence indicates that the hypothalamus coordinates these responses, though the specific brain pathways engaged by leptin remain obscure. The paraventricular nucleus of the hypothalamus (PVH) regulates pituitary gland function and feeding, and innervates autonomic preganglionic neurons, making it a candidate to regu...
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The role of the ventromedial nuclei of the hypothalamus (VMN) in food behavior was studied in adult male rats, allocated in 3 groups: control, sham and lesioned. Electrolytic lesions were induced stereotaxically (1.2 mA, 15 sec). Results revealed a significant decrease (p<O.05) in body weight (BW) and food intake (FI) in the order of lesioned <sham <control during the fIrst week. However, ...
متن کاملventromedial hypothalamic nuclei and feeding behavior
the role of the ventromedial nuclei of the hypothalamus (vmn) in food behavior was studied in adult male rats, allocated in 3 groups: control, sham and lesioned. electrolytic lesions were induced stereotaxically (1.2 ma, 15 sec). results revealed a significant decrease (p
متن کاملThe projections of the dorsomedial hypothalamic nucleus in the rat.
The dorsomedial hypothalamic nucleus (DMH) output pathways are revealed by using autoradiographic tracing of tritium labeled Leucine and by the recently introduced Phaseolus vulgaris leuco-agglutinin immunocytochemical method. Terminal labeling appears in the dorsal motor nucleus of the vagus, nucleus ambiguus and in the parvocellular reticular formation at the lower medullary level. Mesencepha...
متن کاملModulatory effect of ventromedial hypothalamic D2 receptors on leptin and glucose concentration
Introduction: A specific role of dopamine D2 receptor signaling of midbrain and hypothalamic dopaminergic systems has not been yet identified in energy homeostasis. Here, we investigated effects of intra-ventromedial hypothalamus (VMH) administration of the D2 receptor agonist (quinpirole) and antagonist (sulpiride) on plasma leptin and glucose levels in fasted rats. Methods: A guide cannul...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1998
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.95.2.741